Discovery of 6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)- pyridazinebutanoic acid (FK 838): a novel non-xanthine adenosine A1 receptor antagonist with potent diuretic activity

J Med Chem. 1999 Mar 11;42(5):779-83. doi: 10.1021/jm980671w.

Authors

A Akahane¹, H Katayama, T Mitsunaga, T Kato, T Kinoshita, Y Kita, T Kusunoki, T Terai, K Yoshida, Y Shiokawa

Affiliation

¹ Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Company, Ltd., 1-6, 2-chome, Kashima, Yodogawa-ku, Osaka 532-8514, Japan.

PMID: 10072675
DOI: 10.1021/jm980671w

No abstract available

MeSH terms

Administration, Oral
Animals
Diuretics / chemical synthesis*
Diuretics / chemistry
Diuretics / pharmacology
Drug Design
Purinergic P1 Receptor Antagonists*
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry
Pyrazoles / pharmacology
Pyridines / chemical synthesis*
Pyridines / chemistry
Pyridines / pharmacology
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship

Substances

Diuretics
Purinergic P1 Receptor Antagonists
Pyrazoles
Pyridines
FK 838